The most likely area would be the source of the blues in 1920s America, Dockery Plantation. Dockery Plantation's owner allowed employees at his mill to play guitars imported from Mexico during breaks. Among the first crop of musicians: Henry Sloan, Willie Brown, Tommy Johnson, and Eddie "Son" House, and later Howlin’ Wolf and Robert Johnson.
If your journey leads you to search for the infamous crossroads, be sure not to miss the Mississippi Blues Trail that notes markers along the route from deep in the Delta region all the way up to Memphis, TN.
If traveling by air, Memphis will afford you the most travel options, as it is the largest city in this region. See also our tips for traveling to and around Memphis on your music tour.